Manchester United boss Sir Alex Ferguson will hand Phil Jones a start at Champions League opponents Galatasaray.
Jones will get his first start of the season, an important step after a back injury was followed by knee surgery.
"It's a big day for Phil Jones," said Ferguson.
"He's been out all season but has done enough training to make sure his fitness is okay.
"They've all been different types of injuries and because he is young, he's still to develop physically.
"He's only 20 years of age so there's plenty of time for him."