Tonight's Champions League clash with FC Twente is seen as a do-or-die game for Benitez.
Prandelli said: "I hope that Benitez is not playing for his position in the game tonight. He's a great coach and a person of good sense. Inter are paying for the many injuries they have.
"And it's a group that has won so much, so can feel fulfilled unconsciously by the victories of last year.
"For me, Benitez is the right man, who will give stimulus to the whole environment."