The German is on loan from RB Leipzig since January and has become a key player for Spurs.
He had to come off with a leg injury after 30 minutes of their 3-2 north London derby defeat by Arsenal.
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He felt his hamstring," said manager Ange Postecoglou to reporters afterwards.
We will find out the extent of it."
Spurs still have five games remaining this season and must hunt down Aston Villa for fourth spot.