Guardiola insists De Bruyne is ready for the Gunners after picking up a knock last week.
He said: "He is such an important player. It has been a tough season for him with injuries, he has been out for a long time. But he trained really well yesterday so we will see what we're going to do in the next few days.
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"He's played so consistently for many years, that's the most important thing. In important games we need important players, of course, but for the balance of the team we expect everybody to make a contribution.
"We won't put all the responsibility on Kevin, we have to do it all together, with our people as well."