Milan chiefs are targeting Lopetegui to replace Stefano Pioli for next season.
Transfer expert Fabrizio Romano reports Milan have already decided to replace Pioli at the end of the season.
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Pioli is on a contract that runs until the summer of 2025 - but the Italian giants will therefore break it prematurely.
La Gazzetta dello Sport says Lopetegui is Milan's priority replacement for Pioli.
The parties are not yet fully in agreement - but Milan have decided to try to reach agreement with Lopetegui's camp.