City go into the game on the back of their Champions League exit at the hands of Real Madrid.
Pochettino said: "When you play 120 minutes in the Champions League, the effort is enormous and the emotional aspect is not easy to recover when you lose the chance to reach the semi-final.
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"It will be difficult for Manchester City to get back on the pitch straight away against us. We must remember, however, that the Citizens have an incredible team and they will behave in the same way.
"Over the last six-seven years they have proven to be very consistent for us, because they are doing a fantastic job. They play fantastic football, proving they are one of the best teams in the world."