James has missed much of the season with hamstring issues.
Pochettino said: "The most important thing is Reece James is going to be there for us.
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"Then because we have an amazing relationship and of course he is an amazing player.
"It is not easy when you comeback from a long-term injury. The most important thing is he can be available and be part of the squad.
"It is important to finish (the season) with good feelings."