Lopetegui is in contact with Milan about replacing Stefano Pioli next season.
Benitez told La Gazzetta dello Sport: "I don't know the dynamics that deeply, I can say that Julen is an excellent coach.
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"And that taking over from Pioli, who won, will be complicated."
On Italy's Euros, Benitez added: "I believe it is heading towards a new golden era, the potential is there and it's growing. At the European Championships, I put Italy among the favourites together with England, Germany, Portugal and Spain."