The Red Devils have been besieged by injury issues over the past few months, particularly in defence.
As they prepare to take on Arsenal on Sunday, Ten Hag may have some key players back.
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"For over 10 years I am managing, I never had this experience," he said after a 4-0 loss to Crystal Palace.
"So huge, so many injury issues, so I trust all my experience, it can happen once in 10 years.
"Hopefully now I have to wait another 10 to have so many injuries to deal with."
Luke Shaw and Lisandro Martinez may be fit soon, while the club are also hopeful of having Scott McTominay and Bruno Fernandes back.