The Premier League giants are aware they must win their remaining games to pip Aston Villa to a Champions League spot.
However, The Standard has revealed that Ben Davies has added to their injury woes.
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The defender is out of action, with Destiny Udogie also on the sidelines due to a muscle problem.
Manager Ange Postecoglou also lost Timo Werner to injury against Arsenal at the weekend.
He stated after the loss: "Not good (injury news), we had a couple of issues from the game. Timo got a hamstring injury.
There's two-and-a-half weeks left so he will miss the rest of the season and Ben Davies got a calf injury from the (Arsenal) game and he'll miss the rest of the season as well."