The midfielder has left Spurs after injury riddled and disappointing seasons since joining from Lyon.
His contract has been mutually terminated, which will give him the chance to sign anywhere as a free agent.
A statement from the club read: "The club can confirm the departure of Tanguy Ndombele following the mutual termination of his contract, effective from 30 June, upon the conclusion of his current loan spell.
"Signed from Olympique Lyonnais in July, 2019, the midfielder scored on his debut against Aston Villa and went on to make 91 appearances for us in all competitions, scoring 10 goals.
"During his time here, Tanguy had loan spells back at Lyon, Napoli and with Turkish Super Lig side Galatasaray last season. We should like to wish Tanguy all the best for the future."