Manchester United boss Erik ten Hag explained Matthijs de Ligt's substitution in yesterday's win at Southampton.
De Ligt was taken off in the second-half having opened the scoring in the 3-0 win.
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Ten Hag later said: “It looks like (cramp) yes.
“We had internationals, short in the season, some are short in the pre-season, some come from intercontinental flights so then you know you have a 12.30 game and you can struggle.
“Hopefully it’s nothing serious, we have to assess it today, or tomorrow and then we can see.”