Manchester City veteran Mateo Kovacic has been ruled out for several weeks.
The Croatian midfielder is going to be absent for a crucial run of games due to an injury sustained on international duty.
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Manager Pep Guardiola was not clear about the type of injury, but did admit it would be a three to four week absence.
He told reporters on Friday: "It will be a while, three weeks or a month, more or less."
The Premier League champions are enduring a difficult moment, having lost four games in a row in all competitions.
City are already without midfielder Rodri, which means losing Kovacic will force them into a further reshuffle.