Defeat would see the Reds go seven points ahead of Arsenal, with Manchester City already holding a six point gap.
Adams told The Sun: “This is not quite a must-win game but it is a must-not-lose.
“We can’t lose, because then we would not be far off having more chance of winning the Champions League than the title, even this early.
“At the back end of the season, you will also have a City squad that has been rotated and is full of beans. Usually they don’t lose a game.
“You have to stay in touch with your rivals. If you get to April within three points of the title, you still have a chance.”
He added: “Liverpool are confident and Mo Salah is on fire but I have a funny feeling Arsenal will get a point.
“I would love it if we got all three — and if that means getting another red card in the process, so be it.”