Martin Odegaard’s brace, along with goals from Mikel Merino, Jurrien Timber, Ethan Nwaneri, Riccardo Calafiori, and Leandro Trossard, propelled the Gunners past the Dutch side in a thrilling eight-goal encounter.
In doing so, the Premier League giants made history as the first team in the competition to score at least seven goals away from home in a knockout-stage match.
Indeed, Arsenal registered six away goals in a European match for the first time since November 1993, when they routed Standard Liege 7-0 in the Cup Winners Cup.
For PSV, it marked their worst home defeat in European competition, surpassing a 4-0 loss to the Gunners back in September 2002.
They must score at least seven unanswered goals in the return leg in London to secure a quarter-final berth.