Mbappe was taken off on the hour mark and replaced by Goncalo Ramos. It was Ramos who would score the equaliser via a penalty deep into injury-time.
Asked about his decision on Mbappe, Enrique said: "Sooner or later, at some point, we have to learn to play without Mbapp."
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Indeed, with his move to Real Madrid now an open secret, Mbappe has been used more and more sparingly by Enrique.
Mbappe has only played a full game against Real Sociedad in the Champions League, did not play against Lille and entered for half an hour against Nantes.