Morgan Gibbs-White and Danilo struck at Molineux for Forest.
Nuno said: "Tough game, tough to describe. In the first half it was very, very slow, no tempo, which is not good for us . We conceded two easy goals, but we reacted well and in the second half we had chances to win the game, but unfortunately we could not do it. We needed to win this game.
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"Tactically we tried to press Wolves as they build with a back three, putting them under pressure, not allowing them to play. It wasn't always possible.
"We needed this game, the urgency that we have on points and we could not achieve it.
On the relegation battle, he added: "It is tough but we have to fight until the end. We have a lot of tough games ahead of us so we need to keep going and try to improve in the next game at Everton."