Casemiro was dropped to the bench for the game by his head coach, which United won 2-1 against Manchester City.
However, the Brazilian veteran is said to have told Ten Hag to remove him from the squad due to injury.
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Per BBC Sport, he stated that his hamstring was tight and that he could not make it through any minutes.
The 32-year-old is likely to leave the club in the summer after a disappointing season.
Casemiro was signed from Real Madrid under Ten Hag's say so in the summer of 2022.