Going into the game, the Liverpool defender claimed winning trophies means more to their fans than City's.
Erling Haaland and Ruben Dias have since responded and Guardiola said: "They defend the club not by responding to this guy but what they have done for many years on the pitch every three days.
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"That is the best way. I could answer but why? It is what it is.
"I'm incredibly proud of what we have done and I don't need that to feel that my players are really trying to do it."