The Croatian may have to miss out on their Champions League quarter final first leg against Real Madrid.
City take on Los Blancos in Spain for the first leg, before taking on Real at home.
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Nathan Ake and Kyle Walker are also absent, which will leave City short at the back.
He travelled but he is a doubt," Guardiola said in his press conference.
It is what it is. Also Madrid have (Thibaut) Courtois, (Eder) Militao and (David) Alaba, a long time they have been without players.
Kyle unfortunately in a friendly game was injured. We would love to have him but what can I say?
Injuries are part of a long season but unfortunately in a decisive part of the season we have a number of injuries in the same area and we have to find a solution."