De Bruyne was furious at Guardiola and the rest of the coaching staff after being taken off during a 1-1 draw with Liverpool.
Guardiola chose to shore up his midfield with Mateo Kovacic instead of continuing to use De Bruyne further forward to support Erling Haaland.
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Commentator and ex-Manchester City star Gary Neville stated on Sky Sports: "Well that tells you all you need to know about how Liverpool are controlling this game.
He's having a little whinge at Pep Guardiola, well actually it's a big whinge! He's still going, look.
"This ground does something to them, we know how good City are, they're one of the best teams in the world but Anfield never goes well for them and it hasn't in this second half."