Malo Gusto is the latest who has suffered a blow that could keep him out for some time.
Late in Chelsea's draw against Burnley on Saturday, Gusto had to come off due to a hamstring injury.
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He appeared to be clutching his hamstring as he came off, which will worry Pochettino.
The Argentine head coach is under serious pressure, with many in the club's supporter base looking for him to be sacked.
Robert Sanchez, Ben Chilwell and Carney Chukwuemeka are three others who have been added to the Blues' treatment table in recent weeks.