Maresca, who led the club to promotion from the Championship in his only season at the King Power Stadium, has joined Chelsea.
As he put pen to paper on a five-year deal, which includes a club option for a sixth, Leicester issued a statement about his departure.
It read: "Leicester City Football Club can today confirm the departure of Enzo Maresca from his position as first team manager.
"Given the promising foundations established during his single season in charge, the Club is disappointed that Enzo has decided at this stage that he no longer wants to be part of our vision.
"However, with Enzo’s decision made and the Board’s terms for his departure met, we wish him well in his future endeavors. He leaves with the appreciation of everyone at the Club for his work in helping us to achieve an immediate return to the Premier League during the 2023/24 season.
"Staff members Willy Caballero, Danny Walker, Michele De Bernardin, Marcos Alvarez, Javier Molina Caballero and Roberto Vitiello will also be leaving the Club.
"The Board will now commence the process of appointing a new manager that will lead our return to the Premier League and continue the implementation of our long-term vision for the success of Leicester City Football Club."