On Saturday, attention turns to the relegation battle as the likes of Cdiz CF, RC Celta and Rayo Vallecano are all in action. First up is RC Celta vs UD Las Palmas, as the Galician side look to take advantage of the Canary Islanders' poor form, with Los Amarillos having failed to win any of their past seven.
Rayo Vallecano are still not safe from the threat of relegation, so they'll hope to take all three points when they welcome CA Osasuna to Vallecas, especially given that their home form has been very good under new coach Iigo Prez.
At 18:30 CEST on Saturday, there is another huge match. In the entire matchday, perhaps only ELCLASICO stands out above Valencia CF vs Real Betis in terms of potential significance. That's because Valencia CF currently occupy the final European qualification position, but they're only two points above Los Verdiblancos and could be overtaken if Manuel Pellegrini's side storm Mestalla and take the win.
The final game of Saturday then sees Girona FC clash with Cdiz CF. The Catalan side may have won 1-0 when they met earlier this season, but it should be kept in mind that Cdiz CF went down to 10 men after just 10 minutes that day. They'll expect to battle with 11 players for longer this time around.
Sunday is ELCLASICO day and the action begins with Real Sociedad's visit to Getafe CF, with La Real looking to make sure they qualify for Europe next season. For Takefusa Kubo, this means a return to one of his former clubs and he'll look to prove himself at the Coliseum.
Next up, UD Almera host Villarreal CF and everyone tuning in should make sure to watch until the very end of each half. That's because Villarreal CF's 2-1 victory from their previous meeting was achieved with a goal in the fifth minute of first-half stoppage time and in the fourth minute of second-half stoppage time.
Deportivo Alavs vs Atltico de Madrid is next up and it'll be interesting to see how Diego Simeone's side respond to their midweek Champions League elimination. Keen to ensure they qualify for the same competition next year, Los Colchoneros will have to be at the top of their game, especially given that their on-loan striker Samu Omorodion is able to take on his parent club.
Then, at 21:00 CEST, it's time for ELCLASICO, the match that will be watched around the world. Real Madrid and FC Barcelona will put on a show at the Bernabu, giving their maximum in search of the three valuable points on offer. The home side know that a win would extend their lead at the top to 11 points, but that defeat to Bara would reduce it to just five. With this being Xavi's final ELCLASICO, he'll make the trip with extra motivation, keen to make his mark at a stadium where he has achieved huge wins as a player and as a coach. It promises to be a spectacle that no football fan will want to miss.
There is one final Matchday 32 fixture on Monday night, when Sevilla FC and RCD Mallorca meet in the Andalusian capital. For Javier Aguirre's side, this means a return to the city where they just lost the Copa del Rey final and they won't want to board the flight home following another disappointing result.