La Gazzetta dello Sport says Inter have opened their eyes to Wan-Bissaka. He is considered a potential replacement for Denzel Dumfries.
The Dutchman has yet to agree a new contract with Inter, prompting rumours that he could be sold this summer.
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Inter have previously been in contact with Wan-Bissaka's agents, and they believe the right-back could be attracted by the prospect of playing outside England.
The fullback is also seen as a more likely signing than Fiorentina defender Michael Kayode, who Inter are also said to be interested in.
Wan-Bissaka's contract with United runs until the summer of 2025.