The Dutchman has struggled during a loan spell at Eintracht Frankfurt in the Bundesliga.
Van de Beek has barely played and the 26-year-old has not impressed when given a chance.
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Per Fabrizio Romano, a buy option will not be activated and Van de Beek will have to find another team.
United are not likely to want to hold onto him, given he has barely featured for the club since Erik ten Hag's arrival as manager.
Despite playing for his countryman at Ajax, Van de Beek is not in Ten Hag's good graces at United.