The Real Madrid great is said to be a candidate to replace Thomas Tuchel at Bayern at the end of the season.
But Desailly told Sport1: Bayern have few players who adapt to Zidane's philosophy and his 4-3-3. The club should spend a lot of money to fix the team and adapt it to his needs.
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"But why not do it? If Bayern really wants a radical change this would be the right opportunity."
Desailly also said of Kingsley Coman and his possible recovery in view of this summer's European Championships: It will be difficult for him to be at the European Championships.
"After the injury, however, he must improve physically and find his path and the role that best suits him."