The young attacker is on-loan at Brighton this season from Barca.
"He is a great, great talent. But I don't know," De Zerbi said, according to Mirror journalist Ryan Taylor.
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"I have to talk to Tony (Bloom, the club owner), the sporting director, scouts and the recruiting staff. Then I will talk to Ansu Fati."
Fati is on a contract with Barcelona that runs through the summer of 2027.