The Seagulls go to Fulham on Saturday.
De Zerbi said: "For sure the target is to beat Roma, if we are speaking about Europe so we can play in the quarter-final.
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"In the Premier League, it's to keep this level. We want to reach the last five games of the season in this position in the table. To reach this target we need more players in terms of numbers and not many injuries otherwise it will be tough.
"If you watch the game against Wolves, (Simon) Adingra didn't play well. It wasn't because he's not a good player or because of his attitude, but maybe he is tired. Facundo (Buonanotte) is the same, Pascal Gross suffered cramp at the end of the game. Lewis Dunk can't play 90 minutes every three days. So to make substitutions I need to have more players available."