The Albion are pushing to finish in a European position in the Premier League table.
However, they are now set to be without winger Kaoru Mitoma for the next few months.
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Mitoma has a back injury, with De Zerbi stating to reporters: It is an important problem.
I think two, three months But two, three months is finished the season."
Evan Ferguson is another who is injured, while Danny Welbeck is a doubt for their next game.
De Zerbi added: "We keep working with enthusiasm, with pride. Try to transform the problem into opportunities, like we have done until this moment.
Don't worry, we fight to try to win the game, at Fulham the same, in Rome the same."