Ramos, 53, resigned as Sevilla coach on Saturday morning and Spurs have asked Leeds if they can invite Gus Poyet to work as Ramos's assistant.
Ramos said: "It is a squad any coach would be excited to work with. There is potential to achieve great things."
Newspaper reports suggest he will be paid up to £6m a year by Spurs.
Marcos Alvarez, 36, who worked with Ramos at Sevilla, will also join the Tottenham coaching staff.