The 21st-placed Eagles grabbed a crucial 1-0 home win over previously third-placed Cardiff City last night and the Republic of Ireland man can sense a vulnerable Rangers outfit after they fell to Millwall 2-0.
Palace take on Neil Warnock’s men at Loftus Road and McCarthy is tipping an upset.
“We can go into the game with confidence,” he said.
“We know we will have our work cut out at Loftus Road, QPR are deservedly top. I’m sure that we will give QPR the respect they deserve but we will go there looking for a result and I am confident we have enough to get one.
“Dougie (Freedman) knows exactly what needs to be done, not only this season but for the future, and I think you can see things are already changing around here.”