Neymar struck twice in Barcelona's 3-0 win over Celta Vigo.
The evening turned sour when Victor Valdes was carried off with a serious knee injury that could end his Barca career and rule him out of the World Cup.
The goalkeeper struggled to hold on to a free-kick from Fabian Orellana midway through the first half and landed on his right knee as he gathered the ball, and was seen crying as he was taken off the pitch, replaced by Sergio Pinto.
It could be Valdes' last appearance for the club, with the player set to depart Barcelona in the summer when his contract runs out.
Neymar had given the Catalans the lead after six minutes, and Messi doubled the advantage on the half hour, before Neymar struck again midway through the second period.
"I liked the first half. We maintained possession, we passed well, we went deep and we had pace. I didn't like our second half but I don't want to go overboard with my analysis because the game was marked by an action (Valdés) that really hurt us," said Barca coach Tata Martino.
