Middlesbrough defender Robert Huth has been forced to pull of the Germany squad to face Switzerland in midweek.
Huth has returned to England after reporting to Germany's training camp with an ankle problem - and team doctors have ruled him out of Wednesday's friendly with the Swiss.
The news is a blow for Huth as he has not played for Germany since the 2006 World Cup finals.
The former Chelsea defender could face a fight to win a place in the Germany squad for Euro 2008 as the Swiss clash is the final warm-up game before Low names his squad for the finals this summer.