The Football Association has charged Jonny Evans and Papiss Cisse after the pair clashed on Wednesday night.
Manchester United defender Evans and Newcastle United striker Cisse, who has accepted the charge, were involved in an altercation during the Red Devils' eventual 1-0 win at St James' Park with both players appearing to spit one each other.
The FA has opted to take retrospective action after the incident was missed by referee Anthony Taylor and both players now face suspension if found guilty.
"The charges relate to an alleged breach of FA Rule E1[a] in that in or around the 38th minute of the game the two players spat at each other," read a statement on the FA's official website.
"The incidents were not seen by the match officials but caught on video. Both players have until 6pm on Friday 6 March 2015 to respond to the charge.
"In Premier League matches, if an incident has not been seen by the match officials, a three-man panel of former elite referees will be asked by The FA to review the footage independently of each other.
"They will then advise what, if any action, they believe the match referee should have taken had it been witnessed at the time.
"For an FA charge to follow, all three panel members must agree it is a sending-off offence.
"In this instance, the decision by the panel was unanimous in respect of both players."
Last season, Hull City midfielder George Boyd received a three-game ban for a similar incident when he allegedly spitting at Manchester City goalkeeper Joe Hart.
