Manchester United midfielder Ander Herrera rates their clash with Sunderland the "biggest game of the season".
United need to bounce back from Saturday's defeat to Swansea City.
"I think it's the biggest of the season, the next game is always the biggest," he told manutd.com. "We can regain third position because Southampton had a tough game [against Liverpool]. Our goal is to be in the top four, to get Champions League football and win the FA Cup - we don't want to drop out of the top four.
"We didn't beat Sunderland at the start of the season, and now we have a good chance to beat them at home. We respect all our rivals, but we must start the game on top."