Manchester United - unbeaten at home this season - play host to Arsenal while holders Chelsea will face League One Huddersfield at Stamford Bridge.
The Fifth Round draw:
Bristol Rovers v Southampton
Cardiff City v Wolves
Sheff Utd v Middlesbrough
Liverpool v Barnsley
Man Utd v Arsenal
Preston v Portsmouth
Coventry v West Brom
Chelsea v Huddersfield
Ties to be played weekend 16/17th February.