Danny Wilson will partner Sotirios Kyrgiakos at the back - and the pair are likely to be joined in defence by Fabio Aurelio and Martin Kelly.
Hodgson told Liverpoolfc.tv: "Martin Kelly and Danny Wilson will start against Steaua Bucharest and it's a great opportunity for them to stake a claim to be in the first team.
"Not being able to take the points we deserved against Tottenham has kept us in a mid-table position so the next games coming up are going to be very important.
"I've got to be careful not to risk too many of the players I want out on the field against Aston Villa.
"Torres won't travel. I can leave maybe as many as six or seven players who I expect to start against Aston Villa out of the team.
"It means on paper I'm taking a weakened team, but I believe people like Joe Cole, Ryan Babel, Milan Jovanovic, Danny Wilson, Christian Poulsen and Jonjo Shelvey are more than capable of doing a good job for Liverpool Football Club."