Manchester United could face old boy Cristiano Ronaldo's Real Madrid while Chelsea could tackle old boss Jose Mourinho's Inter Milan when the Champions League draw is made on Thursday. All the English sides are guaranteed positions among the eight top seeds meaning they will avoid current European champions Barcelona, but could face Real Madrid, who are one of the eight second-ranked clubs.
The draw will see 32 teams split into eight groups, each containing a top seed, a second seed, a third seed and a fourth seed.
Bayern Munich, AC Milan and Sevilla are other top seeds.
Lyon, CSKA Moscow and Juventus are among the second seeds, while Atletico Madrid, Bordeaux and Stuttgart are in the third pot.
Real Madrid are the favourites, not forgetting the final in May will be at their home ground the Bernabeu.