It's Serie A versus the Premier League for the Champions League round of 16.

Chelsea and Arsenal must both pass Italian tests in the last 16 of the Champions League after the draw in Nyon.

The London clubs are the last remaining Barclays Premier League sides in the competition following the exits of Manchester United and Manchester City in the group phase.

But managers Andre Villas-Boas and Arsene Wenger must overcome Serie A opponents if they are to reach the quarter-final stage, with Chelsea drawing Napoli and the Gunners landing AC Milan.

Elsewhere, Barcelona face Bayer Leverkusen and the holders, who have advanced to the final of the FIFA Club World Cup in Japan, will be confident of progressing against a side currently sixth in the German Bundesliga.

Their arch-rivals Real Madrid will also be satisfied after pulling out CSKA Moscow.

Bayern Munich, who host the final, were paired with Basle while 2010 champions Inter Milan will face Marseille.

Zenit St Petersburg take on Benfica and Lyon were pulled out against last 16 surprises APOEL Nicosia.